Aspirin is an established, safe, and low-cost medication in long-standing common use in the prevention and treatment of cardiovascular diseases, and in the past a pain relief and fever-reducing medication.
The use of aspirin was very popular during the 1918 Spanish Influenza pandemic, several decades before in-vitro confirmation of its activity against RNA viruses.
Studies showed that aspirin, in addition to its well-known anti-inflammatory effects, could modulate the innate and adaptive immune responses helping the human immune system battle some viral infections.
In a recent study at Bar-Ilan University, researchers suggest that pre-infection treatment with low-dose aspirin (75mg) use might have a beneficial effect on COVID-19 risk.
The study is published in The FEBS Journal. One author is Prof. Eli Magen.
In the study, the team analyzed data of 10,477 persons who had been tested for COVID-19 during the first COVID-19 wave in Israel.
Aspirin use to avoid the development of cardiovascular diseases in healthy individuals was associated with a 29% lower likelihood of COVID-19 infection, as compared to aspirin non-users.
The proportion of patients treated with aspirin was much lower among the COVID-19-positive individuals, as compared to the COVID-19-negative ones.
And those people who had been treated with aspirin were less likely to have COVID-19 infection than those who were not.
Moreover, the team found that the conversion time of SARS-CoV-2 PCR test results from positive to negative among aspirin-using COVID-positive patients was much shorter, and the disease duration was two three days shorter.
The team says the findings of the possible beneficial effect of low doses of aspirin on COVID-19 infection are very promising.
They intend to investigate a larger cohort of patients and in randomized clinical trials.
If you care about COVID-19, please read studies about people died of COVID-19 have these 3 common symptoms and findings of this common stomach drug may help fight COVID-19.
For more information about COVID-19 prevention and treatment, please see recent studies about this health problem a key sign of COVID-19 in frail, older people and results showing that these pre-existing conditions may double or triple mortality risk for COVID-19 patients.
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