This study shows big differences between severe and mild COVID-19

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In a recent study from La Jolla Institute for Immunology and elsewhere, researchers found that people with severe COVID-19 cases may be left with more of the protective “memory” T cells needed to fight reinfection.

The finding suggests people with severe COVID-19 cases may have stronger long-term immunity.

The study is published in Science Immunology. One author is Professor Pandurangan Vijayanand, M.D., Ph.D.

Since early in the COVID-19 pandemic, the researchers had examined which antibodies and T cells are important for fighting SARS-CoV-2.

They had used sequencing tools to uncover which T cell subsets may control disease severity.

In this study, they tested the expression of individual genes of more than 80,000 CD8+ T cells isolated from both COVID-19 patients and non-exposed donors.

CD8+ T cells are the cells responsible for destroying virus-infected host cells. “Memory” CD8+ T cells are also important for protecting the body from reinfection against many viruses.

The team studied CD8+ T cells from 39 COVID-19 patients and 10 people who had never been exposed to the virus (their blood samples were given before the pandemic).

Of the COVID-19 patients, 17 patients had a milder case that did not require hospitalization, 13 had been hospitalized, and nine had needed additional ICU support.

To the researchers’ surprise, they saw weaker CD8+ T cell responses in patients with milder COVID-19 cases.

The researchers saw the strongest CD8+ T cell responses in severely ill patients who required hospitalization or ICU support.

In fact, CD8+ T cells in the milder cases showed the molecular signs of a phenomenon called T cell “exhaustion.”

In cases of T cell exhaustion, cells receive so much immune system stimulation during a viral attack that they are less effective in doing their jobs.

The team thinks it is worth testing whether T cell exhaustion in the mild COVID-19 cases may hinder a person’s ability to build long-term immunity.

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