In a new study, researchers found that the chemicals present in white button mushrooms may slow the progression of prostate cancer.
Androgens, a type of male sex hormone, promote the growth of prostate cancer cells by binding to and activating the androgen receptor, a protein that is expressed in prostate cells.
The scientists found white button mushrooms appear to suppress the activity of the androgen receptor
The research was conducted by a team at the Beckman Research Institute of City of Hope.
Previously, the team did a clinical trial of white button mushroom powder in patients with recurrent prostate cancer, which showed that the mushrooms reduced levels of prostate-specific antigen (PSA) in the blood, with minimal side effects.
Heightened blood levels of PSA in men may indicate the existence of prostate tumors.
In the current study, the team examined the mushroom extract’s effect on prostate cancer cells that were sensitive to androgen.
They found that in prostate cancer cells, white button mushroom extract suppressed androgen receptor activity.
They also found that in mice treated with white button mushroom extract for six days, prostate tumor growth was strongly suppressed, and levels of PSA decreased.
The findings showed that white button mushrooms contain chemicals that can block the activity of the androgen receptor in mouse models, indicating this fungus can reduce PSA levels.
While more research is needed, the team says it’s possible that white button mushrooms could one day contribute to the prevention and treatment of prostate cancer.
The study was presented virtually at ENDO 2021. One author of the study is Xiaoqiang Wang, M.D., Ph.D., M.B. (A.S.C.P.)
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