In a recent study from Saint Louis University, researchers found that high fat or “ketogenic” diets could completely prevent, or even reverse heart failure caused by a metabolic process.
They found drastic heart failure could be bypassed by switching to high fat or “ketogenic” diets, which could completely prevent, or even reverse the heart failure.
These findings suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure.
The study is published in Nature Metabolism. One author is Kyle S. McCommis, Ph.D.
The heart’s myocardium requires vast amounts of chemical energy stored in nutrients to fuel cardiac contraction.
To maintain this high metabolic capacity, the heart is flexible and can adapt to altered metabolic fuel supplies during diverse developmental, nutritional, or physiologic conditions.
Impaired flexibility, however, is linked to cardiac dysfunction in conditions including diabetes and heart failure.
In the study, the team found that this heart problem can be prevented or even reversed by providing a high-fat, low carbohydrate “ketogenic” diet”.
A 24-hour fast in mice, which is also “ketogenic” also provided strong improvement in heart remodeling.
Diets with higher fat content, but enough carbohydrates to limit ketosis also strongly improved heart failure in mice lacking cardiac MPC expression.
This study reveals a critical role for mitochondrial pyruvate utilization in cardiac function and highlights the potential of dietary interventions to enhance cardiac fat metabolism to prevent or reverse cardiac dysfunction.
The findings suggest that the consumption of higher fat and lower carbohydrate diets may be a nutritional intervention to treat heart failure.
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