In a new study, researchers found that a simple eye exam combined with powerful artificial intelligence (AI) machine learning technology could provide early detection of Parkinson’s disease.
The research was conducted by a team at the University of Florida.
Parkinson’s disease is a progressive disorder of the central nervous system that affects millions of people worldwide.
Diagnosis is typically based on symptoms like tremors, muscle stiffness, and impaired balance—an approach that has big limitations.
The issue with that method is that patients usually develop symptoms only after prolonged progression with a significant injury to dopamine brain neurons.
This means that doctors are diagnosing patients late in the disease process.”
Disease progression is characterized by nerve cell decay that thins the walls of the retina, the layer of tissue that lines the back of the eyeball.
The disease also affects the microscopic blood vessels, or microvasculature, of the retina.
These characteristics present an opportunity to leverage the power of AI to examine images of the eyes for signs of Parkinson’s disease.
In the study, the team deployed a type of AI called support vector machine (SVM) learning that has been around since 1989.
Using pictures of the back of the eye from both patients with Parkinson’s disease and control participants, they trained the SVM to detect signs on the images suggestive of disease.
The results showed that machine learning networks can classify Parkinson’s disease based on retina vasculature, with the key features being smaller blood vessels.
The proposed methods further support the idea that changes in brain physiology can be observed in the eye.
The single most important finding of this study was that a brain disease was diagnosed with a basic picture of the eye.
This is very different from traditional approaches where to find a problem with the brain you look at different brain images.
The team noted that those traditional imaging approaches with MRI, CT and nuclear medicine techniques can be very costly.
In contrast, the new approach uses basic photography with equipment commonly available in eye clinics to get an image. The images can even be captured by a smartphone with a special lens.
It’s just a simple picture of the eye, you can have it done in less than a minute, and the cost of the equipment is much less than a CT or MRI machine.
If doctors can make this a yearly screening, then the hope is that they can catch more cases sooner, which can help them better understand the disease and find a cure or a way to slow the progression.
The approach may also have applications in identifying other diseases that affect the structure of the brain, such as Alzheimer’s disease and multiple sclerosis.
One author of the study is Maximillian Diaz, a biomedical engineering Ph.D. student.
The study was presented at the annual meeting of the Radiological Society of North America (RSNA).
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