These bone disease drugs may help reverse hearing loss, Harvard scientists find

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Hearing loss caused by damaged nerves, whether from sound exposure or aging, is irreversible.

There are currently no medications approved by the Food and Drug Administration (FDA) to treat and reverse the most common type of hearing loss, called sensorineural hearing loss (SNHL).

In a recent study from Harvard Medical School, researchers found that bone disease medications may reverse hearing loss.

The findings may pave the way for trials to test bone density medications for hearing loss.

The study is published in Frontiers in Molecular Neuroscience. One author is Konstantina Stankovic.

In the study, the team found medications called bisphosphonates, which are commonly used to prevent bone density loss, were able to regrow damaged nerve connections in the inner ear in mice with SNHL.

While the findings require further studying in animal models, the research team hopes it could be a promising target for conducting clinical trials in people with SNHL.

This is an important finding because it opens the possibility for repurposing bisphosphonates, which typically treat severe osteoporosis and metastatic bone disease, for the treatment of sensorineural hearing loss.

The team further suggests that the finding provides possible mechanisms that could explain why some patients in the clinic have improved their ability to recognize speech after bisphosphonate treatment.

They hope the promising results from this pilot study can lead to clinical trials within the next several years.

Disabling hearing loss affects 466 million people worldwide and 56 million in the United States—numbers that are expected to more than double over the next two decades.

Hearing loss can take a toll on health and well-being, and untreated hearing loss costs more than $750 billion in health care spending each year worldwide, due to more hospital stays and greater need for emergency rooms and clinical visits.

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