Scientists find a better way to detect prediabetes

Credit: University of Tokyo

In a new study, researchers have developed a patch of needles connected to a paper sensor for diagnosing conditions such as prediabetes.

Luckily, this patch doesn’t multiply the pain and discomfort of a single hypodermic needle. In fact, these microneedles are painless and biodegradable.

The research was conducted by a team at The University of Tokyo.

Researchers have been trying to develop a practical way to use microneedles—tiny needles less than 1 mm in length—for routine do-it-yourself medical monitoring.

Microneedles are so short that they stay within the skin and do not make contact with any neurons, meaning that they cause no pain.

Rather than extracting blood, they draw up fluid in the skin that contains most of the important biomarkers that blood tests look for.

Several types of microneedles exist, but until now, making a practical device that quickly analyzes the fluid has proved elusive.

To make the patch, the researchers first made the microneedles by pouring a melted mixture of a biodegradable polymer and salt into the cone-shaped cavities of a micro-mold while applying heat.

Then they flipped the mold and needles upside down and placed them on top of a piece of paper, this time applying high pressure from above.

The high pressure forced the mixture into the pores of the paper, securing the attachment and allowing fluid drawn through the needles to pass effortlessly into the paper.

After removal from the mold, the needles were cooled in a solution that sucked out all the salt, leaving behind thousands of holes, or pores, which are what the fluid flows through on its way to the paper.

The salt concentration was a key factor they needed to optimize, testing several concentrations of salt to determine how porous the microneedles should be.

To finish the patch, they used double-sided tape to attach a paper glucose sensor onto the paper base of the needle array.

The team tested the patch on an agarose gel in which glucose had been dissolved.

Fluid from the gel flowed from the gel into the porous microneedles, and from there into the paper and the sensor layer. The glucose concentration was accurately recorded as color changes in the paper.

The patches are disposable, biodegradable, and using them does not require any medical expertise or training.

They are also biocompatible, meaning that there is no problem if any remain in the skin when the patch is removed.

The team says prediabetes testing is just one application of the technology. The paper-based sensor can vary depending on the biomarker people wish to monitor.

One author of the study is Beomjoon Kim.

The study is published in Medical Device & Sensors.

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