In a new study, researchers found five biomarkers in the blood associated with higher odds of clinical deterioration and death in COVID-19 patients.
The findings will help physicians better predict outcomes for COVID-19 patients in the U.S.
The research was conducted by a team at George Washington University.
When the researchers first started treating COVID-19 patients, they watched them get better or get worse, but they didn’t know why.
Some initial studies had come out of China showing certain biomarkers were associated with bad outcomes. There was a desire to see if that was true for our patients here in the U.S.
The research team tested 299 patients diagnosed with COVID-19 admitted to GW Hospital between March 12 and May 9, 2020.
Of these patients, 200 had all five biomarkers being evaluated – IL-6, D-dimer, CRP, LDH, and ferritin.
Elevated levels of these biomarkers were linked to inflammation and bleeding disorder, showing an independent increased risk for ICU admission, invasive ventilatory support, and death.
The highest odds of death occurred when the LDH level was greater than 1200 units/l and a D-dimer level was greater than 3 μg/ml.
The team hopes these biomarkers help physicians determine how aggressively they need to treat patients, whether a patient should be discharged, and how to monitor patients who are going home, among other clinical decisions.
Currently, doctors determine risk for COVID-19 deterioration and death based on age and certain underlying medical conditions, like having an immunocompromised state, obesity, and heart disease.
Performing a simple blood test for patients admitted to the emergency department, then also making decisions based on biomarkers present, may further aid point-of-care clinical decision making.
The research team will continue to analyze this data to help physicians make more informed decisions for patients, as well as help hospitals that may need to stratify resources.
One author of the study is Juan Reyes, MD, an assistant professor of medicine at the GW School of Medicine and Health Sciences.
The study is published in Future Medicine.
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