Scientists find new drug to treat aggressive breast cancer

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In a new study, researchers have discovered a way to slow the growth of breast cancer stem cells.

The finding could eventually lead to combination drug therapies on previously untreatable breast cancers.

The research was conducted by a team of British and American scientists.

Around three-quarters of women who have breast cancer have what are known as estrogen receptor-positive tumors.

Some breast cancer cells have receptors that bind to the hormone estrogen and depend on it to grow.

Though anti-estrogen drugs such as tamoxifen and fulvestrant are able to prevent reoccurrence in most of these breast cancers, tumors reoccur in one out of four cases.

Many of the women relapse after several years because some of the cancer cells remain after treatment.

The cells, called cancer stem cells, lay dormant in the body and cannot be targeted by anti-estrogen therapies.

Scientists have now found that cancer stem cells resistant to anti-estrogen drugs express an immune system-related receptor called interleukin 1 receptor.

The team found that a biological inhibitor of this receptor called Anakinra, used to treat rheumatoid arthritis, was able to reduce the ability of the cancer stem cells to form colonies in vitro.

However, further validation in animals and humans is required before the team to confirm if drugs targeting interleukin 1 receptor could be used as an effective treatment.

The team says resistance to anti-estrogen therapies in breast cancer patients is a major problem and one which cancer scientists have been trying to address for many years.

They hope that women who have increased numbers of cancer stem cells and do not respond to currents treatment could one day benefit from combination therapy.

One author of the study is Dr. Bruno Simões.

The study is published in Stem Cell Reports.

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