Scientists find a new way to reduce chronic low back pain

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A recent study at the University of Rochester found that tanezumab, a monoclonal antibody that inhibits nerve activity, provides relief in patients with chronic low back pain.

This demonstration of efficacy is a major breakthrough in the global search to develop non-opioid treatments for chronic pain.

There were also improvements in function linked to the reduction in pain severity.

This is the first study that shows long-term relief for chronic low back pain with a single dose of tanezumab delivered under the skin once every two months.

The study was conducted in 191 sites across eight countries in North America, Europe, and Asia.

The findings are published in Pain. One author is John Markman, M.D., director of the Translational Pain Research Program.

Chronic low back pain is one of the leading reasons why people seek medical care and the number one cause of disability worldwide

Researchers are increasingly finding that certain proteins circulating in the bloodstream heighten the sensitivity of cells in the nervous system to pain.

One of these proteins, called nerve growth factor (NGF), may explain why some individuals experience more intense and chronic back pain. Tanezumab is an NGF inhibitor.

The patients with chronic low back pain enrolled in this study did not previously have relief with at least three different types of pain medication, including opioids, and were considered “difficult-to-treat.”

Tanezumab has not been linked to the often serious adverse side effects seen with opioids or nonsteroidal anti-inflammatory drugs (NSAIDs), which are often used to treat low back pain.

However, this class of drugs has been linked to joint problems, which are sometimes serious enough to require joint replacement.

Because of this concern, the researchers followed participants for an extended period and determined there was a low rate of serious joint problems requiring joint replacement.

They say that in the future, clinicians may have to weigh the different risks of lumbar fusion surgery, chronic opioid use, or NSAIDs against the unique risks of a rare but rapidly progressive form of joint problem associated with blocking nerve growth factor.

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