In a new study, researchers found that an investigational vaccine, mRNA-1273, designed to protect against the COVID-19 virus, was generally well tolerated and prompted neutralizing antibody activity in healthy adults.
The experimental vaccine is being co-developed by researchers at NIAID and at Moderna, Inc. of Cambridge, Massachusetts.
Manufactured by Moderna, mRNA-1273 is designed to induce neutralizing antibodies directed at a portion of the coronavirus “spike” protein, which the virus uses to bind to and enter human cells.
The research was conducted by a team at Kaiser Permanente Washington Health Research Institute and elsewhere.
In the study, the first participant received the candidate vaccine on March 16.
This paper details the initial findings from the first 45 participants ages 18 to 55 years enrolled at the study sites in Seattle and at Emory University in Atlanta.
Three groups of 15 participants received two intramuscular injections, 28 days apart, of either 25, 100, or 250 micrograms (mcg) of the investigational vaccine.
All the participants received one injection; 42 received both scheduled injections.
In April, the trial was expanded to enroll adults older than age 55 years; it now has 120 participants. However, the newly published results cover the 18 to 55-year age group only.
Regarding safety, no serious adverse events were reported. More than half of the participants reported fatigue, headache, chills, myalgia, or pain at the injection site.
Systemic adverse events were more common following the second vaccination and in those who received the highest vaccine dose.
Data on side effects and immune responses at various vaccine dosages informed the doses used or planned for use in Phase 2 and 3 clinical trials of the investigational vaccine.
The interim analysis includes results of tests measuring levels of vaccine-induced neutralizing activity through day 43 after the second injection.
Two doses of vaccine prompted high levels of neutralizing antibody activity that was above the average values seen in convalescent sera obtained from persons with confirmed COVID-19 disease.
A Phase 2 clinical trial of mRNA-1273, sponsored by Moderna, began enrollment in late May. Plans are underway to launch a Phase 3 efficacy trial in July 2020.
One author of the study is Lisa A. Jackson, M.D., MPH, of Kaiser Permanente Washington Health Research Institute in Seattle.
The study is published in The New England Journal of Medicine.
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