Low testosterone levels have been linked to a higher risk of death in middle-aged and older men, but results from large studies are inconsistent.
Studies have also linked sexual dysfunction with mortality in older men.
In a recent study KU Leuven-University Hospitals in Belgium, researchers found that men with erectile dysfunction have a higher risk of death, regardless of their testosterone levels.
The study is published in the Journal of the Endocrine Society. The lead author is Leen Antonio, M.D., Ph.D. from KU Leuven-University Hospitals.
The study used data from the European Male Ageing Study (EMAS), a large observational study that was designed to investigate age-related hormonal changes and a broad range of health outcomes in elderly men.
The researchers analyzed data from 1,913 participants in five medical centers.
They analyzed the link between their hormone measurements and sexual function at the beginning of the study, and whether they were still alive more than 12 years later.
During the average follow-up period of 12.4 years, 483 men—25%—died.
The team found that in men with normal total testosterone levels, the presence of sexual symptoms, particularly erectile dysfunction, increased the risk of death by 51% compared with men without these symptoms.
Men with low total testosterone levels and sexual symptoms had a higher risk of death compared with men with normal testosterone levels and no sexual symptoms.
Men with erectile dysfunction, poor morning erections, and low libido had a higher mortality risk compared to men with no sexual symptoms.
In men with these three sexual symptoms, the risk of dying was almost 1.8 times higher compared to men without symptoms.
In men with just erectile dysfunction, the risk of dying was 1.4 times higher compared to men without erectile dysfunction.
Levels of free testosterone (the testosterone that is easily used by the body) were lower in those who died.
Men who had the lowest levels of free testosterone had a higher risk of death compared to men who had the highest levels.
The team says as both vascular disease and low testosterone levels can influence erectile function, sexual symptoms can be an early sign for increased cardiovascular risk and mortality.
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