In a new study, researchers have launched a Phase III clinical study to test whether a medication used to treat rheumatoid arthritis and other inflammatory disorders might also have therapeutic value for COVID-19 patients.
These patients have developed or at high risk of developing serious lung damage from SARS-CoV-2 infections.
The research was conducted by a team at UC San Diego Health.
Tocilizumab, marketed as Actemra, is an immunosuppressive drug used primarily to treat rheumatoid arthritis and systemic juvenile idiopathic arthritis, a severe form of the disease in children.
The antibody-based therapy works by blocking cellular receptors for interleukin-6 (IL-6), a small protein or cytokine that plays an important role in triggering inflammation as an early immune response to disease.
In some patients with COVID-19, however, the immune response runs amok, overexpressing IL-6 and generating a “cytokine storm,” which can lead to potentially life-threatening damage to lungs and other organs.
Cytokine storms have been linked to a number of inflammatory diseases, from respiratory conditions caused by coronaviruses such as SARS and MERS to some forms of influenza to non-infectious diseases such as multiple sclerosis and pancreatitis.
Previous research has suggested elevated levels of IL-6 are associated with higher mortality in people with community-acquired pneumonia.
In the early days of the novel coronavirus outbreak in Wuhan last year, Chinese physicians used tocilizumab to treat a small number of COVID-19 patients with serious lung damage and reported promising results.
The Chinese National Health commission now includes tocilizumab in its guidelines for treating COVID-19-related pneumonia and other lung issues.
The team says there is increasing evidence that COVID-19 can dramatically impact patients in many different ways, not least by severely damaging inflamed lungs.
The mechanism of tocilizumab suggests a way to dampen and halt that inflammatory response, which might reduce the need for more extreme medical interventions, such as mechanical ventilation, and greater risk of chronic injury and death.
The new clinical trial will enroll approximately 330 participants at nearly 70 sites across the world. For its arm of the trial, UC San Diego will recruit up to 20 participants.
Participants must be 18 years or older and hospitalized with diagnosed COVID-19 pneumonia and evidence of impaired gas exchange.
Participants will receive one intravenous infusion of either tocilizumab or the placebo, with a possible second infusion if clinical symptoms worsen or show improvement.
Funding and resources for the trial are provided by the pharmaceutical company Genentech/Roche, which makes Actemra.
One researcher of the study is Atul Malhotra, MD, research chief of pulmonary, critical care, and sleep medicine at UC San Diego Health.
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