Dementia gene could double risk of severe COVID-19

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In a new study, researchers found that having a faulty gene linked to dementia doubles the risk of developing severe COVID-19.

They found a high risk of severe COVID-19 infection among European ancestry participants who carry two faulty copies of the APOE gene (termed e4e4).

The research was conducted by a team at the University of Exeter Medical School and elsewhere.

One in 36 people of European ancestry have two faulty copies of this gene, and this is known to increase risks of Alzheimer’s disease up to 14-fold* and also increases risks of heart disease.

Now, the research team has found that carrying these gene mutations doubles the risks of COVID-19—even in people who had not developed these diseases.

The team has previously found that people with dementia are three times more likely to get severe COVID-19, yet they are not one of the groups advertised to shield—or shelter in place—on health grounds.

Part of the increased risk effect may have been exposed to the high prevalence of the virus in care homes.

However, the new study shows that a genetic component may also be at play.

The team found that people with the APOE e4e4 genotype were at double the risk of developing severe COVID-19, compared to those with the common e3e3 form of the APOE gene.

The team used data from the UK Biobank study, which collects health and genetic data on 500,000 people.

The majority of people in the population and in the sample size have not yet been exposed to the virus.

In this analysis, 2.36% of participants with European ancestrieshad the ApoE e4e4 faulty gene, but 5.13% of those who tested positive for COVID-19 had this gene variant, suggesting the risk is doubled compared to e3e3.

The team says this is an exciting result because scientists might now be able to pinpoint how this faulty gene causes vulnerability to COVID-19.

This could lead to new ideas for treatments. It’s also important because it shows again that increasing disease risks that appear inevitable with aging might actually be due to specific biological differences.

One author of the study is Dr. Chia-Ling Kuo from the UConn School of Medicine.

The study is published in the Journal of Gerontology: Medical Sciences.

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