Higher levels of coronavirus marker found in lungs of smokers and people with COPD

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In a new study, researchers found that people with chronic obstructive pulmonary disease (COPD) and people who currently smoke may have higher levels of a molecule, called angiotensin-converting enzyme II (ACE-2), in their lungs.

The research was conducted by a team at the University of British Columbia and St. Paul’s Hospital.

Previous research shows that ACE-2, which sits on the surface of lung cells, is the ‘entry point’ that allows coronavirus to get into the cells of the lungs and cause an infection.

The new study also shows that levels of ACE-2 in former smokers is lower than in current smokers.

The team says the data emerging from China suggested that patients with COPD were at higher risk of having worse outcomes from COVID-19.

They hypothesized that this could be because the levels of ACE-2 in their airways might be increased compared to people without COPD, which could possibly make it easier for the virus to infect the airway.

The team studied samples taken from the lungs of 21 COPD patients and 21 people who did not have COPD.

They tested the samples to gauge the level of ACE-2 and compared this with other factors, such as whether they were from people who never smoked, were current smokers or former smokers.

Not only did they find higher levels of ACE-2 in COPD patients, they also found higher levels in people who were smokers.

The researchers then checked their new findings against two existing study groups, which together contain data on a further 249 people—some non-smokers, some current smokers and some former smokers.

Again, they found levels of ACE-2 were higher in current smokers but lower in non-smokers and in those who were former smokers.

The team says patients with COPD and people who are still smoking have higher levels of ACE-2 in their airways, which might put them at an increased risk of developing severe COVID-19 infections.

Patients with COPD should be counseled to strictly abide by social distancing and proper hand hygiene to prevent infection.

The team also found that former smokers had similar levels of ACE-2 to people who had never smoked. This suggests that there has never been a better time to quit smoking to protect yourself from COVID-19.

The leader of the study is Dr. Janice Leung at the University of British Columbia and St. Paul’s Hospital.

The study is published in the European Respiratory Journal.

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