Misuse of opioids may change the brain permanently

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A recent study from the University of California San Diego found that opioid dependence may produce permanent changes in the brain.

They reported that dependence on oxycodone, a potent opioid painkiller, led to permanent changes of a brain-wide network that modulates the transmission of pain.

When researchers restored nociceptin levels in the network, it resulted in normalization of GABAergic transmission and a reduction opioid consumption.

The study is published in PNAS. One author is Giordano de Guglielmo, PharmD, Ph.D., assistant professor in the Department of Psychiatry.

Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10% developing an opioid use disorder or addiction.

Every day, according to the National Institute on Drug Abuse, more than 130 people in the United States die after overdosing on opioids.

Two out of three drug overdose deaths involve an opioid. From 1999 to 2017, the last year for which data is available, almost 400,000 Americans lost their lives to opioids, with 47,600 fatal overdoses in 2017 alone.

It’s estimated 2.1 million Americans have an opioid use disorder.

Currently, opioid maintenance therapy is the first-line treatment for opioid dependence, which involves using alternative, less damaging medications, such as methadone, buprenorphine, and naltrexone.

These three drugs are the only treatments approved by the U.S. Food and Drug Administration, but all have limitations, either because they act against different receptors, pose safety concerns or are less effective due to the need for strict adherence to treatment.

Both methadone and buprenorphine target mu-opioid receptors in the brain.

The new study builds upon past studies suggesting the nociceptin system and its receptors (NOP) are also involved in opioid tolerance and reward, addiction to multiple drugs and modulation of stress.

Interestingly, while the research demonstrates that NOP is implicated in the development of opioid dependence, it conversely blocks the effects of morphine-based opioids.

The researchers say several efforts are already underway testing small molecule drugs that target the nociception system, and have produced positive effects in reducing alcohol-seeking behaviors and biology in rats.

The new findings show they may offer similar potential medical benefits for opioid addiction.

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