In a new study, scientists at Karolinska Institutet find that one of the building blocks in the calcium channels in the pancreatic beta cells play an important role in regulating our blood glucose values.
This means treatments targeting this building block may be a new way to combat type 2 diabetes.
Beta cells in the pancreas produce the hormone insulin, which regulates the blood glucose level in our bodies.
In diabetes, the beta cells have lost part or all of their function. Calcium ions (Ca2+) act as an important signal for the release of insulin.
When blood glucose increases, this causes the levels of Ca2+ in the beta cells to increase, triggering the release of insulin.
Under normal conditions, the Ca2+ signal displays a specific regular pattern when the cells are stimulated by glucose.
When, on the other hand, the beta cells are not able to release normal amounts of insulin, as in diabetes, this pattern changes.
The level of Ca2+ increases in the beta cell when a specific calcium channel, made up of several different building blocks, opens in the beta cell’s wall.
Previous research has shown that one of the building blocks in the channel, the so-called β3 subunit, plays an important regulatory role.
In the new study, the research group reduced the amount of the β3 subunit in the beta cells in the diabetic mice.
The Ca2+ signal normalized and thereby the release of insulin, resulting in better regulation of the blood glucose levels.
They also saw that mice that totally lacked the β3 subunit demonstrated a better beta cell function and blood glucose regulation when they were given a diabetogenic diet.
When the researchers tried transplanting beta cells without the β3 subunit into mice with diabetes, the blood glucose regulation of the mice improved.
Moreover, experiments with human beta cells showed that the release of insulin deteriorates with increased amounts of the β3 subunit.
The researchers suggest that this building block in the calcium channel can be a new target for treating type 2 diabetes.
Even in type 1 diabetes manipulation of the beta 3 subunit may be beneficial in order to establish better functioning insulin-secreting beta cells for transplantation.
Per-Olof Berggren, Professor at the Rolf Luft Research Centre for Diabetes and Endocrinology at the Department of Molecular Medicine and Surgery at Karolinska Institutet, led the study.
The study is published in the scientific journal Cell Reports.
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