Recent research has developed a new drug that could help fight inflammation in the body.
The new anti-inflammatory drug molecule has a new mechanism of action.
It can inhibit a certain protein and decrease the signals that trigger inflammations.
In the study, a multidisciplinary team led by Karolinska Institutet in Sweden found the new drug molecule by acting on a protein responsible for inflammation in cells.
The group has focused on how DNA is repaired by the body for many years. Their aim is to fight cancer by targeting damage to the tumor cells’ DNA.
According to the researchers, the finding could lead to a new treatment for congenital breast and ovarian cancer.
The team discovered that the so-called PARP inhibitor also dampened inflammation when they were developing a new molecule for inhibiting the enzyme that repairs oxygen damage to DNA
The PARP inhibitor has been available for some years, but this is the first time scientists found evidence that it could decrease inflammation.
They also found that the enzyme OGG1, apart from repairing DNA, also triggers inflammation.
The inhibitor blocks the release of inflammatory proteins, such as TNF alpha. In trials on mice with acute pulmonary disease, the researchers succeeded in dampening the inflammation.
The team suggests their discovery may help develop a new treatment for a very serious condition.
Currently, the team is developing an OGG1 inhibitor and examining whether it can lead to new treatments for inflammatory diseases such as sepsis, COPD and severe asthma.
The leader of the study is Thomas Helleday.
The study is published in Science.
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