Silicone breast implant may strongly increase risk of autoimmune disease

Women with breast implants mostly only had to worry about leaks.

However, in a new study, researchers confirmed that almost 1 in 4 implantation patients is at risk of a serious autoimmune disorder.

This large-scale Israeli study was performed in collaboration with researchers from the University of Alberta.

The team found that the risk of women with breast implantation developing an autoimmune disease was 45% higher compared to women without implants.

While some previous studies have shown similar risks, their results were criticized because the diagnoses were self-reported.

This study used a physician-based registration so it’s the first to confirm the relationship exists between implants and autoimmune disorders based on diagnoses made by doctors.

The researchers compared nearly 25,000 Israeli women with breast implants with nearly 100,000 women without an implant.

Previous research conducted by the team showed that surgical mesh implants, often used for a hernia or gynecological repair, maybe the reason so many patients report symptoms of an autoimmune disorder.

Specifically, they found that 45% of patients developed an autoimmune disorder such as lupus or rheumatoid arthritis after a mesh implantation and patients who had allergies before the implant was significantly worse after.

The new study also found the strongest links between silicone breast implants and Sjögren’s syndrome (autoimmune disorder of the salivary and tear glands), systemic sclerosis (autoimmune disorder of the connective tissue affecting the skin, arteries and visceral organs such as lungs and kidneys) and sarcoidosis (autoimmune disorder of the lung, skin and lymph nodes).

The causal theory behind both breast and mesh implants and autoimmune disorders is that there’s an instant activation of the body’s immune system when a foreign material is put in it.

It continues to fight the foreign body and eventually, over time, fatigues and may become dysfunctional.

The team suggests that concerned patients should discuss risks with their physicians about existing or future breast or mesh implants.

The United Kingdom, Scotland, Australia and New Zealand have already put holds on mesh implantation.

In addition, patients in the Netherlands who are planning a breast implant are warned about the increased risks of developing autoimmune disorders if they already have allergies.

In Canada, there are no rules (yet) in place.

The U.S. health regulators say they’ll convene a public meeting of medical advisers next year to discuss new science on breast implant safety.

This includes an independent analysis that suggests certain rare health problems might be more common with silicone gel implants.

Bottom line, there is clear evidence that implantation of foreign bodies in humans is not without risks in patients who are genetically predisposed to an autoimmune disorder.

This is why screening measures, such as warning women who already have pre-existing autoimmune diseases or allergies of the increased risk, need to be put in place before surgery.

Jan Willem Cohen Tervaert, director of the Division of Rheumatology at the U of A, is one study researcher.

The study is published in The International Journal of Epidemiology.

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Source: The International Journal of Epidemiology.