In a new study, researchers found that controlled ingestion of peanut protein could help build tolerance in peanut allergy sufferers.
They say an oral immunotherapy drug they tested could be the first FDA-approved medication of its kind for people with peanut allergy.
The medication, called AR101, is derived from peanut protein.
Researchers in 10 countries across North America and Europe conducted the trial, known as the Peanut Allergy Oral Immunotherapy Study of AR101 for Desensitization trial, or PALISADE, for short.
Of 496 eligible participants ages 4 to 17, 372 received the AR101 oral medication, while the remainder received a placebo drug.
At the end of the trial, more than two-thirds of the group taking the active drug were able to tolerate a dose of peanut protein equivalent to about two peanut kernels.
Almost 6 million American children are currently living with a life-threatening food allergy.
Every three minutes, a food allergy reaction sends someone to the emergency room, contributing to the total annual cost of caring for children with a food allergy of nearly $25 billion.
Despite this, not a single treatment for food allergy has been approved by the FDA.
According to the team, oral immunotherapy for peanut allergy has been recommended against in most clinical settings because past trials have been limited by small sample sizes and differing methodologies.
The PALISADE trial has shown, however, that oral immunotherapy is a reasonable treatment option.
Participants of the PALISADE trial were instructed to continue the standard of care for peanut allergy, which meant eliminating peanuts from their diets and carrying self-injectable epinephrine (an emergency medical treatment for accidental exposure).
Qualifying participants started with a one-day supervised increase in dosage from 0.5 mg of peanut protein up to 6 mg, an increase every two weeks from 3 mg to 240 mg and a 24-week “maintenance phase” at 300 mg.
When adverse reactions occurred, the study protocol allowed for adjustments to the dosing schedule.
Compared to the placebo group, participants who took AR101 had less severe allergy symptoms.
Before this treatment, families have been living with constant anxiety that one wrong bite will send their loved one to the emergency room, or worse.
Now, people have a safety net that will prevent an allergic reaction if they accidentally take a bite of a peanut-containing food.
Christina Ciaccio, MD, MSc, associate professor of pediatrics and medicine at UChicago Medicine, is a study co-author.
The study is published in the New England Journal of Medicine.
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Source: New England Journal of Medicine.
