In a new study from the University of Eastern Finland, researchers found that regular physical activity could significantly change the body’s metabolite profile, and many of these changes are linked to a lower risk of type 2 diabetes.
Previous studies have not established the association of physical activity with the metabolite profile.
In the current study, the team examined the association of physical activity with metabolite profile, insulin sensitivity, insulin secretion and risk of type 2 diabetes.
7,000 men joined the study and were followed up for eight years. A total of 1,260 metabolites were analyzed from the study participants’ fasting glucose samples.
In the study, men were classified into four categories based on their physical activity: those who were physically inactive, those who were physically active only occasionally, those who were physically active regularly but no more than twice a week, and those who were physically active regularly at least three times a week.
Researchers found that men in the highest physical activity category had a 39% lower risk of type 2 diabetes than men who were physically inactive.
For men in the category of active no more than twice a week, they had a 30% lower risk of type 2 diabetes than men who were physically inactive.
In addition, the study showed that increased physical activity improves insulin secretion.
Researchers also observed lower fasting glucose and insulin levels, and better insulin sensitivity and insulin secretion in men who increased their physical activity during the follow-up.
The findings suggest that the association of physical activity with insulin secretion is clear now. Increased physical activity could improve insulin secretion.
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The study was conducted by Susanna Kemppainen et al. and published in Metabolites.
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