In a new study from Mount Sinai, researchers found vaccination against COVID-19 did not affect fertility outcomes in patients undergoing in-vitro fertilization (IVF).
The findings add to the growing body of evidence providing reassurance that COVID-19 vaccination does not affect fertility.
In the study, the team compared rates of fertilization, pregnancy, and early miscarriage in IVF patients who had received two doses of vaccines manufactured by Pfizer or Moderna with the same outcomes in nonvaccinated patients.
The study involved patients whose eggs were collected from the ovaries and fertilized by sperm in a laboratory, creating embryos that were frozen and later thawed and transferred to the womb, and patients who underwent medical treatment to stimulate the development of eggs.
The two groups of patients who underwent frozen-thawed embryo transfer—214 vaccinated and 733 unvaccinated—had similar rates of pregnancy and early pregnancy loss.
The two groups of patients who underwent ovarian stimulation—222 vaccinated and 983 unvaccinated—had similar rates of eggs retrieved, fertilization, and embryos with normal numbers of chromosomes, among several other measures.
The authors of the study anticipate that the findings will ease the anxiety of people considering pregnancy.
The study will give people comfort to know that the COVID-19 vaccine does not affect their reproductive potential.
The publication of the new study coincides with the surge of the highly contagious Omicron variant.
Previous studies have found that COVID-19 vaccination helped protect pregnant people—for whom COVID-19 substantially increases the risk of severe illness and death—from severe illness, conferred antibodies to their infants, and did not raise the risk of preterm birth or fetal growth problems.
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The study is published in Obstetrics & Gynecology. One author of the study is Devora A. Aharon, MD.
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