Research out of University Minnesota Medical School uncovers what causes diastolic heart failure and how it can be treated.
The study is published in the Journal of Clinical Investigation Insight.
In the article, the researchers found that magnesium can be used to treat diastolic heart failure.
“We’ve found that cardiac mitochondrial oxidative stress can cause diastolic dysfunction. Since magnesium is an essential element for mitochondrial function, we decided to try the supplement as a treatment,” explained lead author Dudley.
“It eliminated the poor heart relaxation that causes diastolic heart failure.”
Obesity and diabetes are known risk factors for cardiovascular disease.
Researchers discovered the magnesium supplement also improved the mitochondrial function and blood glucose in the subjects.
Patients with diastolic heart failure have a high morbidity, mortality, and healthcare costs.
Patients with this condition have similar annual mortality to patients with systolic heart failure, and up until now there was no known specific treatments for this type of heart failure.
“This is an exciting step forward in the cardiovascular field,” said Dudley, “Right now there are no specific treatments for patients with diastolic heart failure, but now we have a theory of why diastolic heart failure occurs and what we can do to get rid of it.”
The next step is human trials. Dudley says this work could also open doors for answers for a related condition, atrial fibrillation.
Source: University of Minnesota.