Older patients with diabetes may be at an 84 percent higher risk of developing postoperative cognitive dysfunction (POCD) than those who are not diabetic, suggests new research.
“With POCD, a patient’s mental ability declines after surgery, compared to their cognitive performance before surgery, resulting not only in increased complications and potential death, but also impairing the patient’s quality of life,” said Gunnar Lachmann, M.D.
“POCD is increasingly recognized as a common complication after major surgery, affecting 10 to 13 percent of patients, with seniors being especially vulnerable.”
POCD is a major form of cognitive disturbance that can occur after anesthesia and surgery, but little is known about its potential risk factors.
An association between diabetes and age-related cognitive impairment is well established, but the role diabetes has in the development of POCD is unknown.
In the study, researchers performed a secondary analysis of three studies, comprising a total of 1,034 patients (481 who had cardiac surgery, and 553 who had non-cardiac surgery), to examine whether diabetes was a risk factor for POCD.
The mean age for the patients studied was 66.4 years. Of the 1,034 patients studied, 18.6 percent had diabetes.
The association of diabetes with risk of POCD was determined using logistic regression models at the longest patient follow-up period for each study, which was 3 or 12 months. Risk estimates were pooled across all three studies.
After adjusting for age, sex, surgery type, randomization, obesity and hypertension, the researchers determined diabetes was associated with an 84 percent higher risk of POCD. Patients age 65 or older were at particularly high risk.
“Our findings suggest that consideration of diabetes status may be helpful for the assessment of POCD risk among patients undergoing surgery,” said Dr. Lachmann.
“Further studies are warranted to examine the potential mechanisms of this association, to ultimately help in the development of potential strategies for prevention.”
News source: American Society of Anesthesiologists (ASA). The content is edited for length and style purposes.
Figure legend: This Knowridge.com image is for illustrative purposes only.