Ebola vaccine is 100% effective after 10 days

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Ebola vaccine is 100% effective after 10 days

An international group of researchers associated with the World Health Organization published its final report on the Ebola vaccine trial in Guinea, finding that the vaccine is a safe and effective way to prevent Ebola infection.

They report the vaccine is 100 percent effective at preventing Ebola when given 10 or more days prior to exposure to the deadly virus. The study findings were published in The Lancet.

“The goal was to estimate the vaccine efficacy from a phase III randomized vaccine trial,” says Ira Longini, a professor in biostatistics at the University of Florida and a key figure in the design of the Ebola vaccine trial and the analysis of its statistical data.

The 2014 Ebola virus outbreak was by far the largest and most lethal Ebola outbreak ever recorded.

Transmission occurred primarily in three West African countries: Liberia, Sierra Leone, and Guinea.

According to the Centers for Disease Control and Prevention, the virus infected nearly 29,000 people in the region, with more than 11,000 deaths.

The trial was called “Ebola ça suffit!” and it was the first successful phase III trial for an Ebola vaccine.

Having successfully completed phase III indicates it has been tested on hundreds of subjects and proven both safe and effective.

If there’s another outbreak

Trial participants were organized into 117 clusters, of which 70 clusters received the vaccine immediately and 47 clusters received it 21 days later.

Disease takes several days—even weeks—to develop following Ebola infection, yet there were zero cases among vaccines more than 10 days after any cluster received the vaccination.

Those in immediately vaccinated clusters who were not vaccinated still received protection, thanks to the trial design—known as a “ring vaccination” trial.

This type of trial creates clusters around contacts of people who have contracted the pathogen, as well as contacts of contacts, since these people are at a higher risk of contracting disease.

Since the immediately vaccinated participants reduced the number of infections, those ineligible for vaccination within immediate clusters benefitted from herd immunity.

According to the report, vaccinating only 52.1 percent of the participants was still 70.1 percent effective in preventing the spread of Ebola.

The vaccine is not available for sale. The WHO has collected a stockpile as a safeguard, just in case another Ebola outbreak occurs.

“We are now helping WHO replicate this experience for all emergency infectious disease threats through the Research and Development Blueprint for Action to prevent Epidemics at WHO,” Longini says.

“This includes the design and analysis plans for Zika vaccine trials.”

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News source: University of Florida. The content is edited for length and style purposes.
Figure legend: This Knowridge.com image is for illustrative purposes only.