At UCSF’s 3-D Imaging Lab, radiologist Judy Yee, MD, pulls up an image that looks more like a birthday party balloon animal than a patient’s colon: a vibrant, color-segmented tube, torqued and twisted in on itself.
Created from thin slices of a computed tomography (CT) scan, the image appears three-dimensional on the flat screen.
It can even morph into video “fly-through” views, enhancing polyps, lesions, and other precancerous anomalies.
Yee refined this revolutionary blend of advanced graphical software and scanning technology – known as CT colonography (CTC) or virtual colonoscopy – as a far less invasive and easier-to-interpret alternative to conventional colonoscopies.
Yee, professor and vice chair of the Department of Radiology and Biomedical Imaging at UCSF and chief of radiology at San Francisco Veterans Affairs Health Care System, is now pushing radiology even further with holograms.
Virtual holography CTC is the latest phase in her two decades of research committed to earlier, safer, life-saving detection of colorectal cancer.
Though the disease is often preventable, it is the second most common cause of cancer deaths in the United States.
“When screening for breast cancer, lung cancer, prostate cancer and other malignancies, we’re typically looking for the cancer itself. By then it’s too late,” Yee says.
“Here we have a specific pathology that allows us to find a lesion (known as a polyp) before it turns into cancer. If we could just get more patients to come in for screening, we could certainly have a huge impact on preventing colorectal cancer.”
Holography: Radiology’s Future?
Yee slips on a pair of 3-D black metal-rimmed glasses and points a laser stylus at the monitor still displaying her patient’s colon.
By flicking the stylus and turning her head while keeping her eyes on the monitor, Yee is suddenly “inside” the colon, moving through it, pulling it toward her, spinning it around.
As she moves, a computer monitor with stereoscopic optical technology tracks her glasses, which have different polarization in each lens, prompting her brain to construct a virtual holographic object that recreates the size and shape of the human anatomy.
The stylus, working in tandem with advanced graphical processing of the CTC image, allows her to “grab” the portion of the scan she wants to examine in more detail and interact with it in three-dimensional space.
“I don’t know of anyone else who is doing this,” Yee says, about UCSF’s blending of radiology with virtual holography.
“You can cut away the parts of what you don’t want to see and manipulate it so that you improve what you do want to see.”
“It’s a more engaging way to read large data sets. With the added dimension, you can see flat, more dangerous lesions better.”
The technology also has far-reaching promise for neurological, cardiac, and musculoskeletal applications, she adds.
“As the equipment evolves, it allows us to view the same disease processes in a completely different way so we can improve detection and diagnostic ability and streamline workflow,” Yee says.
“This could go a long way toward helping show what radiology can bring to patient diagnosis and management for all different parts of the body.”
The ‘Aha’ Moment
A graduate of the Bronx High School of Science, Yee fell for the field of radiology in medical school, where she discovered how imaging blended her rich background in science and mathematics and had a wide variety of applications in medicine.
“We use images to work out the pieces of a puzzle,” she says. “It’s so gratifying to use those pieces to make a patient’s diagnosis and see how the patient responds to treatment. It allows you to participate in a continuum of care.”
Judy Yee (left) says that if more patients would get screened, it could have a big impact on preventing colorectal cancer.
She helped refine the virtual colonoscopy, which doesn’t require sedation, and the low-radiation-dose CT scan takes just 20 seconds. Photo by Noah Berger
Yee got her first look at CTC in 1997, at the annual meeting of the Society of Gastrointestinal Radiology.
Inspired, she raced home and wrote a research proposal to further develop the technology, which she realized – even in its earliest stages – held the promise of a better experience for patients and a more effective screening tool for practitioners.
“Conventional testing for colon cancer was not reducing morbidity and mortality, and cancer rates in some areas were increasing,” Yee says.
“Many individuals were not coming in to get screened for a malignancy that essentially could be prevented. There’s a fear of the invasive procedure.”
Her research has fostered numerous improvements, including lowering the radiation dose per scan by two-thirds, while maintaining high-quality detection of polyps and cancers; decreasing the amount of preprocedure laxative required; and increasing the sensitivity of computer-aided detection.
Yee’s current CTC research includes providing data on the protective effect of negative test results. She hopes to persuade the American Cancer Society to endorse CTC screenings every 10 years – the same schedule as conventional colonoscopy – instead of every five years.
She and her colleagues also are working to remove a financial stumbling block to CTC access: Medicare’s refusal to reimburse for the procedure, even though numerous private insurers cover it.
Although a CTC test costs significantly less than conventional colonoscopy, many Medicare patients may not be able pay for the procedure out of pocket.
“CTC should be the frontline colorectal cancer screening tool, with only those patients who have a lesion sent on to the more invasive colonoscopy,” Yee says.
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News source: UCSF. The content is edited for length and style purposes.
Figure legend: This Knowridge.com image is credited to Noah Berger.