In a recent study, scientists from the University of Granada have shown that eating canola oil (an improved form of rapeseed, with less than 2% erucic acid) enriched with Omega-3 reduces the risk of cardiovascular disease.
Researchers have once again proven that the famous Omega-3 is a potent regulator of cholesterol metabolism.
This time, scientists analyzed the plasma from 84 volunteer patients after they ate different types of oils with different fatty acid composition.
These patients had at least one symptom of metabolic syndrome.
The result showed that fatty acid reduces the PCSK9 concentration in plasma.
PCSK9 is a protein associated with high levels of LDL cholesterol (the bad cholesterol) in blood and with other cardiovascular diseases.
The consumption of high oleic, Omega-3 enriched canola oil not only significantly reduced the concentration of triglycerides (the main constituents of body fat), but also resulted in a significant reduction (a 10%) of the PCSK9 protein concentration in plasma, compared to the other dietary treatments.
PCSK9 protein can destruct the receptors of LDL cholesterol and prevent the uptake of LDL by the cells.
It can increase LDL cholesterol concentrations in plasma, resulting in an increased risk of atherosclerosis and other related diseases.
The finding represents the first line of scientific evidence on changes in the PCSK9 protein plasma concentration after ingestion of different types of fat from the diet.
Citation: Pu S, et al. (2016). Dietary high oleic canola oil supplemented with docosahexaenoic acid attenuates plasma proprotein convertase subtilisin kexin type 9 (PCSK9) levels in participants with cardiovascular disease risk: A randomized control trial. Vascular Pharmacology, published online. DOI: http://dx.doi.org/10.1016/j.vph.2016.06.007.
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