Low-protein diet may help improve blood sugar regulation in obesity

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low-protein diet

Diets that are very high in protein are linked to an increased risk for developing type 2 diabetes, and high protein levels have been correlated to poor insulin regulation.

However, few studies have investigated whether decreasing protein intake could be an effective strategy for lowering the risk of type 2 diabetes and other obesity-related metabolic disorders.

In a new study published in The Journal of Clinical Investigation, researchers from the German Cancer Research Center demonstrate that low-protein diet can improve glucose homeostasis in mice and humans.

They found that in obese mice, low protein diets prevented dysregulation of glucose levels by inducing liver stress signaling pathways.

In addition, low protein diets improved blood glucose homeostasis and other metabolic markers in a small group of healthy young men.

These data indicate that low protein diets activate stress response pathways in the liver that may reduce the risk of developing obesity-related metabolic disorders.

**A low-protein diet is a diet in which people reduce their intake of protein. A low-protein diet is prescribed for those with inherited metabolic disorders, such as Phenylketonuria and Homocystinuria and reduced protein levels have been used by people with kidney or liver disease. Low protein consumption appears to alter the risk of bone breakage, presumably through changes in calcium homeostasis.

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Citation: Maida A, et al. (2016). A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution. The Journal of Clinical Investigation, 126: 3263–3278. DOI: 10.1172/JCI85946.
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