Recently, more and more research evidence shows that a low-calorie, balanced diet can extend longevity and delay age-related diseases.
In a new study led by Chinese Academy of Sciences, researchers find the biomedical mechanism behind the health benefits of a low-calorie diet. The finding is published in Journal of Proteome Research.
Researchers examined how different dietary habits would influence metabolism and longevity. In the study, they fed mice with a high-/low-fat diet with or without reduced calorie intake for more than a year.
Biological markers of metabolism and longevity in the mice were examined with nuclear magnetic resonance analysis.
Researchers found that the high calorie intake had many negative health effects, such as disturbed lipid metabolism and oxidative stress.
On the contrary, low calorie intake avoided or even improved the metabolic conditions.
Moreover, calorie restriction had a much bigger effect on metabolic outcomes than the amount of fat in the diet.
Based on the finding, researchers suggest that controlling calorie in the diet is more important than controlling fat. Furthermore, these beneficial effects of a low-diet can last a long time.
When people are on a low-calorie diet, they usually get between 800 and 1,500 calories a day. For some people, an alternative for short-term weight loss is a low-calorie diet.
Many very low-calorie diets are commercially-made formulas of 800 calories or fewer that replace all the food you usually eat.
When using a low-calorie diet, people should pay attention to potential side effects. Very low-calorie diet may cause fatigue, nausea, anemia, loss of lean muscle mass and gout. It is wise to ask doctors’ and nutritionists’ suggestions before taking a very low-calorie diet.
Citation: Wu J, et al. (2016). Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice. Journal of Proteome Research, 15: 2299-2308. DOI: 10.1021/acs.jproteome.6b00336.
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